Sunderland boss Steve Bruce will be without defender Phil Bardsley through suspension for the game against the Seagulls.
The full-back was sent off for a second bookable offence in Saturday's 1-0 derby defeat by Newcastle and will serve a one-match ban.
Bruce will make changes as some of his summer signings get the chance to prove their worth with keeper Keiren Westwood a likely starter, but the game will come too soon for defender John O'Shea despite his recovery from a hamstring problem and Craig Gordon, Fraizer Campbell and David Meyler (all knee) are still unavailable.
Brighton team news to follow.
Sunderland (from): Mignolet, Westwood, Brown, Richardson, Turner, Bramble, Ferdinand, Laing, Cattermole, Gardner, Vaughan, Colback, Elmohamady, Gyan, Sessegnon, Wickham, Ji, Cook.