Bruno Lage's side are still searching for their first goal and win of the season despite encouraging displays against both Tottenham and Manchester United.
Watford, meanwhile, failed to build on the momentum created by their electric 3-2 victory over Aston Villa on the opening weekend as they tasted successive away defeats to Brighton and Tottenham before the break.
Here's everything you need to know about the game.
How to watch Watford vs Wolves on TV/live stream
When is kick off? Saturday 11 September, 15:00 (BST)
Where is the match being played? Vicarage Road
What TV channel is it on? Final Score (BBC - UK), Soccer Saturday (Sky Sports - UK), fuboTV (US)
Highlights? Sky Sports YouTube Channel (UK - 5.15pm) Match of the Day (BBC - UK)
Referee? Peter Bankes
VAR? Simon Hooper
Watford team news
Xisco Munoz will be without goalkeeper Ben Foster and forward Joao Pedro as both continue to battle fitness issues, while midfielder Dan Gosling is set to miss out.
FIFA are also set to rule on Chile's request for restrictions to be imposed on defender Francisco Sierralta over a refusal from the Premier League to release the player for international duty.
Wolves team news
Bruno Lage does not have his troubles to seek as he wrestles with the long-term absence of the influential Pedro Neto.
Wolves are also set to be without talisman Raul Jimenez with FIFA expected to act upon a request to restrict players from South America and Mexico from featuring for their clubs in the Premier League this weekend.
Lage, however, will have been boosted by the return of Willy Boly to the squad prior to the international break.
Watford vs Wolves predicted lineups
Watford: Bachmann; Cathcart, Troost-Ekong, Kabasele, Masina; Etebo, Cleverley, Kucka; Sarr, Dennis, Sema
Wolves: Sa; Kilman, Coady, Saiss; Semedo, Neves, Moutinho, Marcal; Trincao, Silva, Traore
Watford vs Wolves head-to-head
The Hornets edged the previous meeting between these two sides on New Year's Day in January 2020 thanks to goals from Gerard Deulofeu and Abdoulaye Doucoure.
Watford boast a marginally superior head-to-head against the Molineux side - 16 wins to 15 defeats - with their most memorable recent encounter coming in the semi-finals of the FA Cup in 2018/19.
Wolves raced out to a two-goal lead at Wembley against the Hornets before Watford staged a late comeback which was capped off by Troy Deeney's injury time winner from the penalty spot.
Watford vs Wolves score prediction
Wolves have been a thrilling attacking side under the guidance of Bruno Lage so far and only a bout of bad luck in front of goal prevented them from taking all three points against both Tottenham and Manchester United.
They have been aided by a boisterous Molineux crowd, however, and their last away league outing yielded an uninspiring 1-0 defeat to Leicester City on the opening weekend which will concern the Wolves faithful.
Watford netted three times in their Premier League opener at Vicarage Road and Xisco Munoz boasts the attacking firepower to trouble the Wolves rearguard.
Prediction: Watford 2-2 Wolves