The Carabao Cup third round draw has taken place with Manchester United vs West Ham, Arsenal vs AFC Wimbledon and Manchester City vs Wycombe Wanderers some of the standout ties.
City have won the competition four years in a row and will be confident of progressing when League One Wycombe travel to the Etihad Stadium next month.
Another third-tier side, AFC Wimbledon, have also been handed an intriguing tie. Mark Robinson's side have drawn Arsenal, who were the last team to qualify for the third round courtesy of an emphatic 6-0 win over West Brom.
United have a far trickier task. David Moyes will be looking to get one over his former employers when he brings his high-flying Hammers to Old Trafford.
A number of other Premier League clubs will be squaring off in the competition too. Chelsea face a trip from Aston Villa, Norwich are hosting Liverpool and Nuno Espirito Santo will be taking Tottenham to his former club Wolves.
Oldham Athletic, the lowest-ranked side left in the Carabao Cup are also taking on top-flight opposition in the form of newly-promoted Brentford.
Meanwhile, Leicester City face an intimidating trip to Millwall, Everton have been handed an away tie against QPR and Leeds United travel down to west London to face Championship table-toppers Fulham, who are unbeaten under new manager Marco Silva.
All of the ties will be contested during the week commencing 20 September.
QPR vs Everton
Preston North End vs Cheltenham
Manchester United vs West Ham
Fulham vs Leeds United
Brentford vs Oldham Athletic
Watford vs Stoke City
Chelsea vs Aston Villa
Wigan Athletic vs Sunderland
Norwich City vs Liverpool
Burnley vs Rochdale
Arsenal vs AFC Wimbledon
Sheffield United vs Southampton
Manchester City vs Wycombe Wanderers
Millwall vs Leicester City
Wolves vs Tottenham Hotspur
Brighton vs Swansea City