After a hectic encounter at home to Cardiff City, Fulham gave themselves the chance to return to the top flight at the first time of asking with a 3-2 aggregate victory.
As for the Bees, they will be looking for their first taste of Premier League football, having not been in the top tier since 1947.
Brentford also won their tie 3-2 on aggregate, seeing off Swansea City in their last ever game at Griffin Park after a 1-0 defeat in the first leg.
Where to Watch
When Is Kick Off? Tuesday 4 August
What Time Is Kick Off? 19:45 (BST)
Where Is it Being Played? Wembley Stadium
TV Channel/Live Stream? Sky Sports (UK)
Championship Golden Boot winner Aleksandar Mitrovic could be set to return for the Whites, having missed both legs of the semi-final against Cardiff with a hamstring injury. Portuguese winger Ivan Cavaleiro may also be available following a thigh problem.
Neeskens Kebano, who has bagged five goals in his last four games, may miss out after going off at half time against Cardiff, while Bournemouth loanee Harry Arter is expected to be sidelined.
The Bees have no new absentees since the victory against Swansea. Nikos Karelis remains out of contention as he recovers from a serious knee injury sustained in October.
Brentford: Raya; Dalsgaard, Jansson, Pinnock, Henry; Norgaard, Jensen, Marcondes; Mbeumo, Watkins, Benrahma.
Fulham: Rodak; Christie, Hector, Ream, Bryan; Reed, Cairney; Knockaert, Onomah, Cavaleiro; Mitrovic.
An astonishing run of eight wins in a row was brought to an abrupt halt for Thomas Frank's Brentford when they succumbed to defeats against Stoke and Barnsley, denying them automatic promotion, and then Swansea in the first leg of the play-off semi final.
The pressure appeared to be getting to the Bees, but they swept this all aside with a dazzling display in the second leg, emerging victorious thanks to goals by Ollie Watkins, Emiliano Marcondes, and Bryan Mbeumo.
As for Scott Parker's side, their defeat to Cardiff in the home leg was their first in nine games, having won six and drawn two of the previous eight.
A concern for Parker may be Fulham's record against Tuesday's opponents. The Whites have only beaten Brentford once in the last ten meeting between the sides, losing six times.
Here is how each side has fared in their previous five outings.
Brentford 3-1 Swansea (29/7)
Swansea 1-0 Brentford (26/7)
Brentford 1-2 Barnsley (22/7)
Stoke City 2-1 Brentford (18/7)
Brentford 1-0 Preston (15/7)
Fulham 1-2 Cardiff (30/7)
Cardiff 0-2 Fulham (27/7)
Wigan 1-1 Fulham (22/7)
Fulham 5-3 Sheffield Wednesday (18/7)
West Brom 0-0 Fulham (14/7)
The Championship play-off final is often a tense affair, with 13 of the last 16 being decided by just one goal or a penalty shootout.
Many of Fulham's squad will not be fazed by the occasion, having beaten Aston Villa at Wembley in a play-off final just two seasons ago.
However, Brentford have scored 16 more goals than their west London neighbours, and conceded ten fewer. With that in mind, Thomas Frank's men surely go into the game as favourites.
Prediction: Brentford 3-1 Fulham