The former England Under-21 international remains on the Blues' books despite spending the last two seasons on loan at Wolves.
The versatile 22-year-old has been forced to look elsewhere after finding his route to the first team at Stamford Bridge blocked.
He now faces a tough choice at a crucial stage of his career, with it unclear where he figures in Carlo Ancelotti's plans.
Mancienne knows that in order to produce his best he needs to feel settled and comfortable in his surroundings.
That is not the case at Chelsea at present and he accepts that a summer switch may now be his best option.
Wolves, who have been impressed by him over recent years, are reported to be keen to strike a deal and Mancienne has hinted that he would be open to such a move.
"I've been at Chelsea since I was a kid and I'd love to break into the first team, but it's hard for any young player knowing how much quality they've got," he told the Daily Express. "I've had two seasons on loan at Wolves and had regular games and really enjoyed it. Now I want to be settled at one club."
While Mancienne has opened the door to a move, he could yet be offered an opportunity to prove his worth under Ancelotti.
Chelsea are set to be without Brazilian centre-half Alex for the start of the new season, while Ricardo Carvalho has expressed a desire to join Real Madrid, leaving a vacancy alongside John Terry at the heart of the back four.