The broadcaster, who has claimed the rights following the demise of Setanta Sports, will screen 46 games in total in the 2009/10 season.
The Gunners' trip to Goodison on the opening day of the campaign will be their first live game, and has been moved to a 5.15pm start.
ESPN live Premier League fixtures:
AUGUST: Saturday 15: Everton v Arsenal (5.15pm); Sunday 23: West Ham v Tottenham (1.30pm); Monday 24: Liverpool v Aston Villa
(8.00pm); Saturday 29: Chelsea v Burnley (12.45pm).
SEPTEMBER: Saturday 12: Tottenham v Manchester United (5.15pm);
Saturday 19: West Ham v Liverpool (5.15pm); Saturday 26: Fulham v Arsenal (5.15pm); Monday 28: Manchester City v West Ham (8.00pm).
OCTOBER: Saturday 3: Manchester United v Sunderland (5.15pm);
Monday 5: Aston Villa v Manchester City (8.00pm); Monday 19: Fulham v Hull (8.00pm); Saturday 24: Chelsea v Blackburn (5.15pm); Saturday 31: Manchester United v Blackburn (5.15pm).
NOVEMBER: Saturday 7: Wolves v Arsenal (5.15pm); Monday 9: Liverpool v Birmingham (8.00pm); Saturday 21: Manchester United v Everton (5.15pm); Saturday 28: Aston Villa v Tottenham (5.15pm).