Egypt international Amr Zaki could have played his last match for Wigan Athletic after being stretchered off the pitch during the 3-1 defeat at West Bromwich Albion.
It is feared that the striker suffered cruciate ligament damage when he landed awkwardly following an aerial challenge.
Zaki's loan spell at the JJB Stadium from Zamalek runs out at the end of the month and boss Steve Bruce is unlikely to make the deal permanent.
Bruce said: "Zaki will be having scans to asses the extent of his injury, but it certainly looks a nasty one. We hope for his sake it's not too serious, but it looked as though he's twisted his knee as he landed.
"From what I've seen anyway, it looks like one of those horrible cruciate ones. We'll know a little bit after the scans."
Of his side's display at The Hawthorns, Bruce added: "We got to our 41-point target with eight games to play and our mentality, no matter how much I've tried to prevent it, has deteriorated.
"I can understand that when you look at where a club like us has come from to where we are now and of course there were huge changes made in January that didn't help.
"But I'm disappointed we couldn't just finish off on a high, as there isn't a lot wrong with how we're playing, we just need to start scoring.
"We've got Manchester United to look forward to on Wednesday now and it's a big chance for us to put things right again."