It was feared Owen's season was in jeopardy when he suffered a groin injury in training last week but happily, the former England star has recovered and could feature at the DW Stadium.
Back in business: Owen will hope to play a part at the DW Stadium
Ryan Giggs is also in contention but Rio Ferdinand (calf), Jonny Evans and Antonio Valencia (both ankle), Park Ji-sung (hamstring) and Anderson (knee) remain sidelined.
Squad: Van der Sar, Kuszczak, Lindegaard, Vidic, O'Shea, Brown, Rafael, Fabio, Evra, Smalling, Scholes, Gibson, Nani, Carrick, Fletcher, Bebe, Obertan, Giggs, Tunnicliffe, Rooney, Owen, Berbatov, Hernandez, King.
CLICK HERE FOR THE WEEKEND TEAM NEWS IN THE BARCLAYS PREMIER LEAGUE Explore more:People: Alex Ferguson, Michael Owen, Ryan Giggs, Park Ji-sung, Bebe, Rio Ferdinand, Antonio Valencia, Nani Places: United Kingdom