Nineteen-year-old Moses has been picked by Pearce for the clash at Doncaster even though Nigeria are keen on getting the young forward to play for them.
A £2.5million signing by Wigan from cash-strapped Crystal Palace last month, Moses was born in Nigeria but left aged 11 following the murder of his parents.
In demand: Wigan's young forward Victor Moses (right) in action
It is a similar situation to that of Manchester City's Nedum Onuoha, who has still not decided where to commit his allegiance.
Pearce cannot imagine being similarly vexed. However, speaking at the launch of the Nationwide Right Hand Fan competition, on behalf of England team sponsors Nationwide, the England Under 21 chief accepts times have changed.
'I am English,' he said. 'If I felt in my heart of hearts I wanted to represent someone else I would make my decision and stick by it.
'But I understand some players might think their chances of playing for a certain country might be limited.
Hopeful: England Under 21 boss Stuart Pearce
'They still want to play international football and go somewhere else. The whole situation has changed quite drastically. We played Germany in the European Under 21 championships last summer and 10 out of their 11 players were eligible to play for someone else. It wouldn't be my choice but there you go.'
What Pearce is certain about is that Moses has talent. The youngster was tipped for big things when he first burst onto the scene at Selhurst Park and Palace owner Simon Jordan only let him leave because his club were in administration.
Wigan are set to benefit - and so are England next Tuesday at the Keepmoat Stadium.
'I can't dictate what he does in the future but I have been on the road and watched Victor play for the Under 19s,' said Pearce.
'He did very well there and we feel he is good enough to be in the squad, so we have picked him.
'I am sure he will be very proud to represent England when he turns up next week and I can't wait for the chance to work with him.'
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