Hugo Rodallega is fast becoming Wigan's lucky talisman this season as his two goals helped secure a 3-1 win and ended Burnley's 100% record at Turf Moor.
The Colombia striker has now scored five goals this season, with all four of Wigan's wins coming when he has been on the scoresheet.
After cancelling out Steven Fletcher's fourth-minute opener just 11 minutes later, Rodallega added his second early after the restart.
That was before a rare Emmerson Boyce strike assured Wigan a first away win since the opening day of the campaign.
Burnley were a shadow of the energetic team that had caused such a stir after victories over Manchester United, Everton, Sunderland and Birmingham on this ground as they lacked momentum and ideas.