The Ecuador winger was strongly linked with a move away from the JJB Stadium during last month's transfer window, but Wigan managed to keep hold of him.
Real Madrid failed in a loan move for Valencia, while Manchester United are believed to be lining up a swoop for the wide-man in the summer.
Bruce is resigned to losing the 23-year-old and he is already looking at possible replacements for Valencia.
Interest"It's inevitable he is leaving. There is so much interest in him - not just in this country but around the world," Bruce told The Mirror.
"We are talking about the biggest clubs in this country and Spain and beyond.
"There was a loan deal put to us by Real Madrid but it was not acceptable. We do have someone in mind to come in, but that is five months off."