Latics boss Roberto Martinez revealed the hamstring injury picked up against Stoke almost a fortnight ago forced the winger to sit out Chile's game with Columbia this week.
Speaking to the Wigan Evening Post, Martinez said: “We did a scan straight after the game and it showed Jean had a tear in the hamstring.
“He has been recovering for the last week and a half, it’s been going well, but it’s still too early to tell whether he’ll be involved on Saturday.
“Jean got the injury in pre-season and that’s never a good thing on the eve of a new campaign.
“He didn’t have any real rest period over the last three years because of the World Cup and the Copa America.
“This one was the first summer in a while where he could actually rest his body after a long and demanding campaign.
“He suffered a couple of niggles trying to reactivate his body that we have to get through, but I’m hopeful he’ll benefit from this period in the long term.
“He is such a special player, such a consistent player, and once he’s fully fit he’ll go back to being a key member of our team.”