Heskey was ruled out of last weekend's 2-1 defeat at West Brom with a knee injury and replaced by Gabriel Agbonlahor.
Missing man: Heskey has not scored for Villa since the start of January
But the former England player has returned to training and is in contention to face the Latics.
Midfielder Jean Makoun will again not be risked with the dead leg which prevented him from facing Albion.
But central defender Richard Dunne has recovered from a similar knock which led to him being substituted early in the second period against the Baggies.
Gary McAllister will again deputise as caretaker manager while manager Gerard Houllier recovers from a heart problem.
Villa (provisional squad): Friedel, Walker, Collins, Dunne, Luke Young, Downing, Petrov, Bannan, Ashley Young, Agbonlahor, Bent, Marshall, Clark, Heskey, Pires, Albrighton, Delph, Reo-Coker, Cuellar, Delph, Delfouneso.
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Explore more:People: Emile Heskey, Ashley Young, Richard Dunne, Gerard Houllier, Gary McAllister, Gabriel Agbonlahor, Luke Young Places: United Kingdom