West Ham are waiting for the results of a scan, but they fear the worst for the 23-year-old midfielder.
Out of the running: Noble picked up a leg injury in the 3-0 defeat at Anfield last weekend
Noble is only just back from two weeks out for an appendix operation but has been one of West Ham's most consistent players this season.
Scott Parker expects to return after missing the defeat at Liverpool with a chest infection but the setback for Noble will be keenly felt at Upton Park.
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