The 17-year-old, earmarked as a Premier League star of the furture, was interviewed by detectives over an alleged sex attack at a party.
The girl claims she was set upon at a property in Herne Hill, south London, last month, sources said.
Arrested: Promising West Ham star Dominic Vose has being quizzed on suspicion of an alleged party attack
Vose, who recently won his first professional contract after being signed for West Ham from Fulham, has been bailed until June.
Officers interviewed Vose last month, taking a DNA swab and fingerprints.
A Scotland Yard spokesman said: 'Officers are investigating an allegation of rape that occurred at an address in Lambeth on Saturday March 26.
'The victim is a 16-year-old girl. A 17-year-old male was arrested by appointment on Sunday March 27 in connection with the investigation.
'He was subsequently bailed to return to a south London police station in June pending further inquiries.'
High hopes: Vose wants to break through the ranks at Upton Park like former stars Joe Cole and Frank Lampard
Vose, likened to Paul Scholes for his midfield potential, signed his professional terms with the Hammers last November despite interest from big clubs Manchester United, Chelsea and Arsenal.
He said then: 'I've just got to crack on now. Hopefully I will make it to the first team. I wanted to sign for West Ham because there is a path here for young players.
'The likes of Joe Cole, Michael Carrick and Frank Lampard -all of them have done it.
'There is a path here and hopefully I can follow that.'
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