Midfielder Mark Noble will miss the clash with the Baggies despite returning to light fitness work this week after having his appendix removed.
Noble was voted as the West Ham fans' Player of the Month for October today, but will miss at least the next two home games with Blackpool also due to visit the Boleyn Ground at the weekend.
Fellow midfielders Jack Collison (knee) and Thomas Hitzlsperger (thigh) remain on the long-term injury list while Tal Ben Haim (foot) and Zavon Hines (knee) are also out.
West Brom will be without midfielder Youssouf Mulumbu after he was sent off for two bookable offences against Manchester City on Sunday.
Defender Gonzalo Jara serves the second of his own three-game ban, while full-back Nicky Shorey is battling to overcome an ankle knock sustained against City.
But Albion boss Roberto Di Matteo is hoping Steven Reid (Achilles) and James Morrison (knee) will be fit.
West Ham (from): Green, Jacobsen, Da Costa, Upson, Ilunga, Gabbidon, Tomkins, Reid, Spector, Behrami, Barrera, Parker, Kovac, Obinna, Cole, Piquionne, McCarthy, Stech, Boa Morte, Stanislas.
West Brom (from): Carson, Shorey, Tamas, Pablo, Cech, Scharner, Brunt, Cox, Thomas, Fortune, Odemwingie, Barnes, Miller, Myhill, Reid, Tchoyi, Dorrans, Morrison.