West Ham will check on James Tomkins ahead of the visit of the Whites.
The centre-half scored the opening goal in Tuesday night's 4-0 win at Watford but limped off in the second half with a hamstring niggle.
Abdoulaye Faye came on to make his debut in place of Tomkins after overcoming the hamstring problem which interrupted his pre-season and he will start if the youngster misses out.
Striker John Carew could be added to the squad, a fortnight after joining on a free transfer, having played an hour for the reserves in midweek.
Left-back George McCartney, who rejoined from Sunderland last week, was also involved as he builds up his match fitness.
Defender Jordan Brown and winger Gary O'Neil (both ankle) are still out.
Leeds skipper Jonny Howson and winger Max Gradel will both return to contention following suspension.
Both players sat out Tuesday night's home win over Hull after being sent off in last weekend's defeat to Middlesbrough and now give manager Simon Grayson a selection dilemma for the trip to London.
Grayson handed a debut to latest signing Andy Keogh in midweek, while winger Ramon Nunez made his first league start for the club as Leeds registered their first points of the season with a 4-1 win.
Luciano Becchio (hamstring) and Billy Paynter (thigh) are not expected to return from injury at Upton Park and fellow striker Davide Somma (knee) remains a long-term absentee.
But midfielder Lloyd Sam is pushing for a place in the starting line-up and Grayson has plenty of options at the back, with Alex Bruce, Andy O'Brien, Paul Connolly and Federico Bessone all featuring in a behind-closed-doors friendly against Middlesbrough this week.