West Ham midfielder Mark Noble will miss the visit of the Seasiders as he continues his comeback after having his appendix removed.
Striker Carlton Cole sustained a hamstring injury in the 2-2 draw with West Brom and is subject to a fitness test.
Midfielders Jack Collison (knee) and Thomas Hitzlsperger (thigh) remain on the long-term injury list while Tal Ben Haim (foot) and Zavon Hines (knee) are also out.
Blackpool boss Ian Holloway must decide how many of the 10 players he left out of Wednesday's 3-2 defeat by Aston Villa to recall for the trip.
The Premier League are investigating whether Holloway fielded a weakened team but the Tangerines manager was adamant the players deserved their chance and admitted they have given him a major headache for Upton Park.
Defender Craig Cathcart will also be in contention after a scan on his knee problem came back clear and he could replace Dekel Keinan, who hobbled out of the game at Villa Park.
West Ham (from): Green, Jacobsen, Da Costa, Upson, Ilunga, Gabbidon, Tomkins, Reid, Spector, Behrami, Barrera, Parker, Kovac, Obinna, Cole, Piquionne, McCarthy, Stech, Boa Morte, Stanislas.
Blackpool (from): Gilks, Kingson, Keinan, Edwards, Eardley, Taylor Fletcher, Crainey, Evatt, Adam, Vaughan, Varney, Ormerod, Campbell, Grandin, Harewood, Southern, Carney, Basham, Euell, Sylvestre, Demontagnac, Phillips, Cathcart.