The former Reds midfielder missed the Hammers' 3-1 win over Chelsea as he was ineligible to appear against his parent club.
Andy Carroll (knee) could be missing for two months but would not have been able to feature against Liverpool due to the terms of his loan, whilst Ricardo Vaz Te (shoulder), Alou Diarra (thigh) and Jack Collison (knee) are all definitely out.
Liverpool striker Luis Suarez is suspended for the trip to Upton Park after accumulating five bookings.
Manager Brendan Rodgers has played midfielder Jonjo Shelvey in a 'false nine' position before and could do so again as a stop-gap with no other senior strikers fit.
Captain Steven Gerrard, left out of the Europa League squad which beat Udinese in Italy because of illness, will be restored at Upton Park as will the rested Daniel Agger and Lucas Leiva.