McCarthy believes Gianfranco Zola left key trio Scott Parker, Mark Noble and Carlton Cole out of his starting line-up for Saturday's defeat at Arsenal in order to ensure they are fresh for the Wolves game.
The Wolves boss, who was punished by the Premier League for resting senior players at Manchester United in December, says Zola's decision to 'target' the Wolves game is a 'slight' upon his team.
Hammered: A weakened West Ham side went down 2-0 to Arsenal at the weekend
'I would take it as a personal slight on me that they have targeted us, and I hope the players do,' said McCarthy.
Enlarge 'But anybody who thinks we're a soft touch has maybe had to revise their opinion slightly.'
Wolves incurred a suspended fine of £25,000 when McCarthy, having seen his team pull off a 1-0 victory at Tottenham, rested 10 players four nights later at Old Trafford, a game they lost 3-0.
McCarthy shrugged off criticism, insisting there was a big injury risk after the effort put in at Spurs and the following Sunday Wolves beat Burnley 2-0 at home to move out of the bottom three. But he says he doesn't think Zola should receive a similar punishment this time.
'Good luck to them. They probably looked at Arsenal as a tough one and thought their best chance of getting points was against us.
'I have no doubt those three (Cole, Parker and Noble) will play against us. I looked at Match of the Day with mild amusement when I saw West Ham's team (at Arsenal). But I don't have a problem with it. You do what's best for your club.'
Fired up: Mick McCarthy has urged Kevin Doyle (R) and co to beat West ham at Upton Park
Zola is under intense pressure after four successive defeats and knows his job will be in the balance if West Ham do not improve against Wolves or in their next clash at home to Stoke City on Saturday.
West Ham v WOLVES: Same again for Mick McCarthy as Molineux men face crunch clashWEST HAM v Wolves: Skipper Scott Parker could return for Gianfranco ZolaWOLVERHAMPTON WANDERERS FC