Remarkably, the friendly is a sell-out, but Capello has announced he could make 11 changes and has already sent home five senior players who played in the 2-0 win in Wales.
Among them are Wayne Rooney and restored captain John Terry, which means there will be a new skipper for the clash.
Read Martin Samuel on England's progress: Grow up and hear this. Capello is on to a winner
No going back: Reinstated captain Terry will be missing for the friendly with Ghana
Fifth choice Gareth Barry who was not even in the 18-man match-day squad in Cardiff is next in line.
'I may make 11 changes because I want to respect the clubs,' said Capello. The other senior players missing are Ashley Cole, Frank Lampard and Michael Dawson. Steven Gerrard and Rio Ferdinand are already absent.
Fans have paid up to ?40 to watch the game the first time Ghana have played England. Amazingly, the World Cup quarter-finalists played an African Nations Cup tie in Congo yesterday, which they won 3-0, so expect lots of tired legs at Wembley.
Lead role: Gareth Barry (far right) is set to captain England against Ghana
They will be greeted by a makeshift lineup, including Phil Jagielka, Gary Cahill, Leighton Baines and Joleon Lescott.
Capello released six players in total, the last being the injured Kyle Walker, who is on loan at Aston Villa from Tottenham. The other five sent back will be involved in the Champions League quarter-finals next week.
The three Spurs players who remain in the squad Aaron Lennon, Peter Crouch and Jermain Defoe will all be in contention against Real Madrid but were not involved in the European Championship qualifier on Saturday.
Slipped my mind: Capello admits he forgot to warn Rooney about a suspension
Scott Parker is a doubt after aggravating his shoulder injury and Capello is unlikely to risk the West Ham midfielder, especially as his relegation-threatened side play Manchester United at the weekend.
Clubs who still have much to play for, however, will be watching to see if theirplayers arrive back safely.
The friendly will at least give Capello a chance tolook at strikingalternatives to Rooney, who will miss thequalifier againstSwitzerland in Junethrough suspension afterbeing booked in Wales.
Amazingly, Capello admitted he forgot to warn Rooney that he was one yellow card away from a suspension.
The England manager also did not tell Ashley Cole and Ashley Young, who were in the same position, but while they came through without a caution, Rooney was booked in the 37th minute after catching Joe Ledley with a reckless challenge just seconds after fouling Andrew Crofts.The England striker left referee Olegario Benquerenca with no choice but to book him.
Afterwards Capello said Rooney was 'surprised' to learn he would now have to serve a one-match ban and that does not reflect terribly well on the Manchester United forward either.
But Capello then admitted that there had been yet another breakdown in communication with his players. Asked directly if the trio had been warned, he said:
'Usually we do this, but this time no.'
Capello eventually took off Rooney, replacing him with James Milner after 70 minutes because he feared he might get booked again.
Clearly, Rooney was a little frustrated by his form and by the fact that he was slightly isolated in his role on the left flank.
'Rooney is too generous, every tackle he wants to win,' said Capello. 'I changed him because with a second yellow card he would have been sent off.'
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Explore more:People: Joleon Lescott, John Terry, Joe Ledley, Fabio Capello, Ashley Young, Phil Jagielka, Gary Cahill, Gareth Barry, Aaron Lennon, Frank Lampard, Michael Dawson, Peter Crouch, Ashley Cole, Wayne Rooney, Rio Ferdinand, James Milner, Jermain Defoe, Steven Gerrard, Martin Samuel Places: Cardiff, Ghana, Wales, Congo, United Kingdom