Winston Reid, George McCartney, Mark Noble and Carlton Cole are likely to return to the starting XI following the convincing 3-0 against FC Rot-Weiss Erfurt on Wednesday.
Two goals from Play-off final hero Ricardo Vaz Te helped The Hammers to their first win in Germany.
Kevin Nolan could once again miss out after picking up an injury in the win over Colchester United.
Trialists Colin Kazim-Richards, Bilel Mohsni and Michael Lamey are likely to get more minutes and another chance to impress Sam Allardyce who is determined to bring in fresh faces to his squad.
Dresden have already faced English opposition this summer, having previously been involved in a 0-0 draw with current Premier League champions Manchester City.