The Baggies boss fears the forward may not be available for Saturday's home Barclays Premier League clash with Liverpool.
Hodgson is upset Vela had to undertake a 12,000-mile round trip for two friendly internationals with Paraguay and Venezuela and did not play a major role in either game.
Flat out: Hodgson expects the travelling to have taken its toll on Vela
The on-loan Arsenal player may not arrive back in England until Friday morning and Hodgson is concerned about what physical condition Vela will be in, plus the effects of jet lag.
Hodgson told the Birmingham Mail: 'I think it is disastrous to have players go away for friendly matches for the length of time it takes to go to Mexico.
'I'm not confident Carlos will come back in the right physical condition.
'I believe he has not played much for Mexico so I think from his personal viewpoint, as a West Brom player, this has been nothing but negative.
Not a happy man: Hodgson (left) may have to do without Vela against the Reds
'I can't see anything positive about him being away for such a long period of time - but I can't stop him going.'
Hodgson does not expect much sympathy from the Mexican FA.
He said: 'They make sympathetic noises but then immediately forget you have phoned because they are not interested.
'They're interested in Mexico. They don't care about West Brom and couldn't care less whether we go stay up or go down.'
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Explore more:People: Roy Hodgson, Carlos Vela Places: Liverpool, United Kingdom, Mexico, Paraguay