West Brom are set to be without central defender Jonas Olsson and striker Marc-Antoine Fortune who were both injured against Fulham, when they travel to Leicester.
Olsson had to be substituted after 55 minutes with an Achilles problem and Fortune at the same juncture with an injury.
Fortune has been deputising for four-goal leading scorer Peter Odemwingie, who has missed the last two games with a knee setback.
But Di Matteo will resist the temptation to rush the Nigerian international back into action.
He said: "We want Peter back as soon as possible but we don't want to rush him back and then lose him for a long time.
"We want him to be back in training this week. That is our aim but we will know more later this week."