Ferguson played the final hour of the Carling Cup win over Arsenal last weekend with a broken rib. Gardner suffered a calf injury and was substituted early in the second half.
Feeling the strain: Craig Gardner (left) looks set to miss out at St Andrews
Playmaker Alexander Hleb has also not recovered from the knee injury which kept him out of the final.
But winger David Bentley and defender Curtis Davies are available after being cup-tied against the Gunners.
Provisional squad: Foster, Taylor, Carr, Parnaby, Johnson, Davies, Jiranek, Ridgewell, Murphy, Larsson, Bentley, Ferguson, Gardner, Bowyer, Fahey, Beausejour, Mutch, Jerome, Zigic, Martins, Phillips, Derbyshire.
CLICK HERE FOR THE WEEKEND TEAM NEWS IN THE BARCLAYS PREMIER LEAGUE Explore more:People: Craig Gardner, David Bentley, Barry Ferguson Places: Birmingham