Manager Chris Coleman has seen his decimated Wales squad lose another key player to injury after captain Ashley Williams was ruled out of the World Cup qualifiers against Macedonia and Belgium with an ankle injury.
Williams had long been a doubt for the double-header due to his ankle ligament injury and Swansea manager Michael Laudrup had made it clear the defender needed a rest.
But, with his squad so severely hit by withdrawals, Coleman would have wanted to field the 29-year-old if possible.
However, the result of a scan on the problem has seen him ruled out, and a Football Association of Wales (FAW) spokesman confirmed to Press Association Sport that Williams would return to his club.
It means Coleman is now without 10 of the 23-man squad he named last week as he prepares for two games which could decide his future.