Tranmere manager Les Parry will be without left-back Zoumana Bakayogo for the trip to Carlisle.
The Paris-born defender was sent off during Saturday's 4-2 demolition of MK Dons and now serves a one-match ban.
Aaron Cresswell is also unavailable due to a hip injury, leaving Parry searching for a deputy to fill in at left-back.
He said: "We've got to deal with that, and for us it's a massive problem. We haven't got that many players to play there so it's not going to be rocket science trying to figure out who's going to play.
"We've still got one or two options."
Midfielder Paul McLaren will also miss the Carlisle game with a back injury but could be available for the weekend's FA Cup tie at Bournemouth.