Aaron Lennon has picked up a groin injury and is set to miss the England Under 21 friendly against Ecuador in Malaga on Tuesday.
Winger Lennon picked up the complaint during yesterday's goalless Barclays Premier League draw against rivals Arsenal, with defender Vedran Corluka coming off with a similar problem.
'Aaron Lennon was struggling with a quarter of an hour to go, we tried to keep him going but he came off and won't be fit for the under-21s,' Redknapp said.
Sidelined: Lennon failed to finish the goalless draw against Arsenal
The stalemate at White Hart Lane against Arsene Wenger's men came despite playing against 10 men following the dismissal of Emmanuel Eboue in the first half. Luka Modric could have snatched the win Redknapp felt his side deserved, although he was still pleased with the performance.
Wilson Palacios, on his home debut, was singled out for praise.
'He'll go on to be a big, big player for his club,' Redknapp said.
Robbie Keane was making his second debut for the club after rejoining from Liverpool.
'It's great to be back,' he said. 'The fans have always been superb to me and it was the same today.'
It could have been a fairytale return for Keane had his 56th-minute header from Lennon's cross gone in, instead of hitting the bar.
Robbie' return: Tottenham fans gave captain Keane a warm welcome
'It was a great ball by Aaron,' he said. 'It didn't go in but we kept plugging away. We were pushing for the whole game, give us credit for that.
'We couldn't break them down but hopefully we can push up the table now.'
Spurs still lie in 15th, while Arsenal are 12 points behind leaders Manchester United and in danger of losing their Champions League place.
Redknapp feels Arsenal will stay in the top four this season.
'Aston Villa have done fantastically well but I have the feeling they will just miss out,' he said.
'It would be nice to see someone break into the top four and Martin O'Neill probably deserves it for what he has done at Villa.
'But Arsenal still are a good side, they've gone 11 without defeat and have good players.'
Spurs 0 Arsenal 0: Eboue sees red but Spurs fail to break down resolute Gunners
TOTTENHAM 0 ARSENAL 0: All the action as it happened
Sorry lads! Red-carded Eboue apologises to Gunners team-mates after north London stalemate
TOTTENHAM HOTSPUR FC NEWS FROM ACROSS THE NET