Keogh is to have ankle surgery after he was injured in training on Thursday.
But Wolves are boosted by the return to the squad of striker Chris Iwelumo after he recovered from the foot injury he suffered against Stoke in October.
Crocked: Keogh faces a lengthy spell on the sidelines
French defender Ronald Zubar, who has missed three games with a thigh strain, will again be absent.
Wolves boss Mick McCarthy is set to name the same side that started last weekend's 2-1 win against Bolton.
Team (from): Hahnemann, Stearman, Craddock, Berra, Ward, Edwards, Henry, Milijas, Jarvis, Doyle, Ebanks-Blake, Surman, Mancienne, Foley, Maierhofer, Castillo, Elokobi, Halford, Hennessey, Iwelumo.
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