Gomes faces a short spell on the sidelines after injuring his groin in Wednesday night's Champions League play-off round second leg against Young Boys, meaning Carlo Cudicini will deputise.
Manager Harry Redknapp must decide whether to play captain Ledley King after his midweek exertions, Luka Modric (groin) is still out, Jamie O'Hara (back) and Jonathan Woodgate are long-term absentees, but David Bentley (ankle) is set to return to training on Monday.
Having demolished the Latics 9-1 in last season's corresponding fixture and facing a side who have conceded 10 goals in their opening two games, complacency can hardly ever have been a greater danger. Redknapp, who praised Wigan chairman Dave Whelan for backing under-fire manager Roberto Martinez, said: "We've been down this road lots of times before, where people expect you to win, and these are always the most difficult games."
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He added: "That's what the good teams do. Good teams play in Europe - Champions League - and they come out and play in the league as well."
Victor Moses will miss Wigan's trip after damaging ankle ligaments in his side's midweek Carling Cup victory over Hartlepool. The England Under-21 international is set to be out of action for two to three weeks, having only just returned after a calf injury.
Steven Caldwell is set to make his Barclays Premier League debut for the club at White Hart Lane but his brother Gary remains sidelined following hip surgery. Wigan manager Roberto Martinez admits his side must improve on their "naive" defending so far this season as they prepare to head to a ground where they conceded nine goals last year.
The Latics have started the 2010-11 Barclays Premier League campaign with 4-0 and 6-0 home defeats to Blackpool and Chelsea respectively, following on from an 8-0 hammering at the hands of Carlo Ancelotti's team on the final day of last season.
They kept a clean sheet in midweek - albeit at npower League One side Hartlepool in the Carling Cup - but now face a return to Tottenham, where they were crushed 9-1 last season. Martinez refuses to compromise on playing positive football but insists his men must wise up at the back.
"I never go for a damage-limitation result, I always want to win and sometimes you are more exposed in that way," he said. "We are very naive and we are still not ready in that department, and it is something we need to sort out very quickly. We need to be a bit different off the ball, a bit more ruthless and a bit more focused.
"You cannot concede cheap goals in the manner that we are doing at the moment. "We are not far away from becoming a very good side but that has to come with hard work on the training ground and with commitment and focus. We have got that in abundance so I am excited, I am really looking forward to the challenge."
Source: DSG
