Winger Aaron Lennon remains sidelined with a hamstring problem while Ledley King (knee) will have a fitness test.
William Gallas could make his first appearance since January after recovering from a calf problem, but defender Michael Dawson (ankle), goalkeeper Heurelho Gomes (knee), and midfielder Tom Huddlestone (ankle) are out.
The Londoners have had an easy route to the last eight, although they have made it hard for themselves with sub-par performances against Watford and Stevenage in the last two rounds.
Boss Harry Redknapp, who lifted the trophy with Portsmouth in 2008, would love to win the competition with Spurs this year and realises that his team have a great chance of going all the way given that they are the top-ranked team left in the competition.
"I would love to win the FA Cup," Redknapp said. "It's a great tournament and we want to go all the way to Wembley now and win it." Chris Eagles is a doubt for Bolton. The midfielder suffered a hamstring injury last weekend after coming on as substitute in the victory over QPR.
England Under-21 striker Marvin Sordell is cup-tied, but Spanish defender Marcos Alonso is in contention for his first game in three months after coming through two reserves games. Owen Coyle is keeping his fingers crossed that Gareth Bale has an off day.
The Bolton manager says he has enjoyed watching the Wales international blossom into one of the best players in the world, but knows he could have a big say in whether Wanderers make it to a second consecutive FA Cup semi-final.
Coyle said: "Gareth Bale is an incredible player and that's why he is coveted by the top clubs in the world - they would all love to have him in their team.
"Tottenham invested in him as a young player and have been very shrewd in that, he's very exciting and a player I personally love watching every weekend.
"I just hope he's not at his best on Saturday but there is no doubt he is a terrific player who can pop up in so many different positions on the pitch. "When he's at the top of his game he is one of the world's best players."
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