Stefano Okaka struck the decisive goal as Anderlecht came from behind to inflict a first defeat of the Europa League group campaign on Tottenham.
Christian Eriksen put Spurs in front after just four minutes but Guillaume Gillet levelled soon after and Okaka - on loan from Tottenham's London neighbours Fulham - sealed a first victory for the hosts with 15 minutes remaining.
Lacina Traore's goal was enough for Monaco to edge past FK Qarabag and leapfrog Tottenham at the Group J summit.
Lazio took a three-point lead in Group G after defying an early red card to beat Rosenborg 3-1 at Stadio Olimpico.
Mauricio was dismissed after only six minutes but Alessandro Matri, Felipe and Antonio Candreva netted for the Serie A side in a match that saw missed penalties at both ends.
Dnipro had been level on points with Lazio but lost 1-0 at home to St Etienne, with Romain Hamouma on target.
Schalke remain atop Group K after a 2-2 draw with second-placed Sparta Prague.
The Czech side came back from an early goal to take a 2-1 lead, only for Leroy Sane to salvage a point for the home side after 73 minutes.
APOEL Nicosia beat Asteras Tripolis 2-1.
Sporting were the evening's big scorers in Group H, despatching Albanian outfit Skenderbeu 5-1, with all six goals coming after Hamdi Salihi's first-half sending off.
Top two Lokomotiv Moscow and Besiktas shared a draw, with goals from Maicon and Mario Gomez.
There were two unexpected away wins in Group I.
Lech Poznan celebrated a 2-1 success at Fiorentina, Dawid Kownacki and Maciej Gajos negating Giuseppe Rossi's late consolation, with Portugal's Os Belenenses surprising Basel by the same scoreline.
In Group L Augsburg got off the mark in style, Piotr Trochowski's goal enough to defeat AZ Alkmaar at home.
Athletic Bilbao ended Partizan Belgrade's 100% record as Raul Garcia and Benat Etxebarria effected a 2-0 win for the visitors.
Source: PA
