The Baggies, who beat Tottenham 2-0 at The Hawthorns earlier in the season, go into the game in buoyant mood following their 3-0 success over Sunderland last time out.
West Brom have a horrible record in London this season having failed to win or even score in the capital.
Tony Mowbray is without two of his key performers for the trip to Spurs with James Morrison and Abdoulaye Meite both sidelined through injury.
Shelton Martis is likely to come in for Meite at the heart of West Brom's defence.
Scottish midfielder Graham Dorrans faces a late fitness test as he struggles to shake off a foot problem.
Spurs will be looking to bounce back from their controversial 5-2 defeat to Manchester United last weekend as they go in search of their fifth successive win at White Hart Lane.
Harry Redknapp is missing top scorer Darren Bent after he suffered a knee injury at Old Trafford.
Roman Pavlyuchenko and the fit-again Jermain Defoe are battling it out to partner Robbie Keane in attack.
Michael Dawson remains sidelined after tearing ankle ligaments earlier this month meaning Ledley King and Jonathan Woodgate should start in central defence.
Possible starting XIs:
Tottenham: Gomes, Assou-Ekotto, King, Woodgate, Corluka, Modric, Palacios, Jenas, Lennon, Defoe, Keane.
West Brom: Carson, Zuiverloon, Martis, Olsson, Robinson, Greening, Koren, Dorrans, Brunt, Simpson, Fortune.