Spurs will be hopeful of a first win of the tour, following draws with both LA Galaxy and Liverpool in their first two games.
Gareth Bale is likely to miss out after picking up an injury from a challenge by Liverpool's Charlie Adam.
Rafael van der Vaart is also set to miss out through injury.
New York could hand a debut to recent arrival Tim Cahill, having signed the Australian from Everton last week.
The Red Bulls suffered a 3-1 loss at Montreal on Saturday and will face Houston on Friday.
Source: DSG
