Defoe blasted his effort straight at Tim Howard to cost Tottenham a 3-2 win, while Lampard squandered a chance to earn Chelsea a point when he failed to beat Shay Given at Eastlands.
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Only John Carew was spot on, the Aston Villa target man scoring their third at home to Hull with only two minutes remaining.
Lamenting his side's downfall in the last 10 miutes of the game, Harry Redknapp said: "There looked to be only one winner.
It was game over as we looked to be in control and I couldn't see any way we weren't going to go on and win. We had chances to go 3-0 up and then they pulled a goal back. It was poor defending, we got sucked in.
"They came on strong and it was a different game for 10 minutes. When you get it back to 2-1 you are going to throw the kitchen sink at the opposition and that is what they did.
"Then we get a great chance to win it with a penalty with the last kick of the game. Robbie Keane is our penalty taker but you'd fancy the little man (Defoe) to score with the form he is in - but it wasn't to be."