The Mexico international is wanted by Sevilla boss Marcelino Garcia Toral, who took Dos Santos on loan to Racing Santander last season.
Now in charge at Sevilla, Toral is seeking a permanent switch for the 22-year-old, but negotiations over the transfer fee have hit a snag.
"I want to play in Sevilla. It is my main preference and this possibility exists but the subject is still not closed," Dos Santos told Spanish website El Desmarque.
"I am still in London but Tottenham desire my sale. My agent is working hard and I hope for a solution next week.
"I prefer La Liga to other countries. I was happy with Marcelino in Santander and it will be sensational to repeat the experience with Sevilla - one of the best European clubs.
He added: "To play next to Frederic Kanoute would be a pleasure."
Dos Santos joined Tottenham from Barcelona in 2008, but has failed to make an impact at White Hart Lane, making just 10 Premier League appearances in that time.