Spurs were linked with an interest in the Canada midfielder late last year but a move failed to materialise.
De Guzman, though, has cast fresh doubt over his Depor future after admitting at an interest in seeking a transfer to the Premier League.
"The (Premier) League is one of the best in the world and if something interesting comes along I will have to consider it," the 29-year-old said in The Daily Mail.
"I cannot rule anything out. My agent is working on this and I know there are clubs who have been asking about me, but we have nothing concrete on the table.
"I know they [Tottenham] have been watching me in games, but I have not spoken with anyone. I am just going to give everything in the final part of the season."