Emmanuel Adebayor has been asked to train with Tottenham's reserves.
Record signing Roberto Soldado has become Spurs' number one striker following his £26million move from Valencia and Jermain Defoe has been first-choice back-up.
Adebayor barely featured in pre-season and he has not played a competitive game after being given extended compassionate leave following the death of his brother in Togo.
Adebayor returned to London towards the end of last month, but he has gone back to Africa, for what Villas-Boas describes as "personal reasons".
The 29-year-old, who is one of Tottenham's top earners, will return on Monday and he will then train with the club's second string.
"At the moment Ade is not with us, because we have granted him authorisation to stay up until Monday in his country for personal reasons, so he's not going to be involved against Norwich (on Saturday)," the Tottenham manager said.
"Up to when I find it appropriate, he will train with the development team."
Adebayor, who signed for Tottenham on a permanent basis last summer, does not appear to be in the club's first-team plans - for the present at least.
Villas-Boas, who sold Gareth Bale to Real Madrid for £85.3million on the penultimate day of the transfer window, has signed seven new players this summer.
The Tottenham boss revealed that one of those signings - Vlad Chiriches - will not feature against Norwich on Saturday as Tottenham are yet to get a work permit for the Romanian defender.