Nick Soolsma scored in the 67th minute to lift Toronto FC to a 2-1 victory over David Beckham's Los Angeles Galaxy on Wednesday and into the CONCACAF Champions League semi-finals.
Jamaica's Ryan Johnson headed home after the half hour mark and set up Soolsma's strike as Toronto overcame an own goal by Ty Harden, which levelled the scores in the 55th minute, to advance 4-3 on aggregate.
The teams were deadlocked at 2-2 in Toronto last week.
Wednesday's defeat was the second setback in five days for Major League Soccer champions the Galaxy, who lost 3-1 to Real Salt Lake in their MLS season opener on Saturday.
Toronto will face Mexico's Santos in the semi-finals.
Santos routed MLS club Seattle 6-1 Wednesday in Torreon. The Sounders won the first leg 2-1 in Seattle, but could not stem the Santos onslaught with Christian Suarez and Herculez Gomez scoring twice and Oribe Peralta and Carlos Ochoa adding a goal apiece.
Uruguayan Alvaro Fernandez scored the lone goal for Seattle, who fell 7-3 on aggregate.
Monterrey booked their semi-final berth with a 4-1 home victory over Morelia for a 7-2 aggregate in an all-Mexican tie.
They face the winner of the tie between El Salvador's Isidro Metapan and Mexico's Pumas, with Metapan taking a 2-1 lead into Thursday's second leg.