Swansea ended Newcastle's four-match winning run with a handsome 3-0 win over Alan Pardew's side at the Liberty Stadium.
Substitute Nathan Dyer, a Mathieu Debuchy own goal and a spectacular Jonjo Shelvey strike gave the Swans just a second home win of the season.
Loic Remy had his header brilliantly saved by Michel Vorm for the visitors, but Newcastle were aggrieved after referee Howard Webb waved away penalty appeals for a Ben Davies handball and an Ashley Williams challenge on Yoan Gouffran in the second half.
Swansea claimed the win despite losing another striker to injury after Alvaro Vazquez limped off with a groin problem.
With Michu and Wilfried Bony also out, and no striker on the bench, the hosts moved midfielder Alejandro Pozuelo into an advanced role and were arguably the better for it as Newcastle struggled to handle their movement.
It was Dyer, Vazquez's replacement, who gave them the lead. Pozuelo drove down the left-hand side of the box and got in a cross that Tim Krul could only tip to the winger, who volleyed home.
Newcastle showed more attacking intent after the break and replays suggested they should have had a penalty in the 57th minute, when Remy's shot cannoned off a combination of Davies' chest and arm.
They were further frustrated when Gouffran tumbled as he and Williams contested a high ball and Swansea broke to clinch the win.
Pozuelo found Shelvey with a defence-splitting pass, the midfielder delayed his shot and Krul saved, only for the ball to rebound off Debuchy and into the net.
But former Liverpool man Shelvey, who a few minutes earlier had feinted to headbutt Debuchy during a heated stand-off, was not to be denied his goal, and curled home from 25 yards to seal the win.
Fourteen years ago to the day, Poyet, then wearing the blue of Chelsea, heading for the away dressing room at the Stadium of Light wondering what had hit him with his side trailing 4-0.
This time around, he found himself on the other side of the corridor facing the task of lifting his players after seeing them take the lead, only for the visitors to mount a powerful fightback.
The Black Cats had slipped back to the foot of the table without kicking a ball on Tuesday evening as a result of Crystal Palace's 1-0 win over West Ham, and they emerged determined to do all they could to address that situation in the most trying of circumstances.
Their initial efforts could not be faulted as they took the game to the Blues with Giaccherini forcing a first-minute block from Cesar Azpilicueta and Fabio Borini sending a cross across the face of goal seconds later.
But keeper Petr Cech was eventually beaten with 17 minutes gone when, after Andrea Dossena's tame free-kick had come back of the wall, Jack Colback slipped the ball to Altidore and he span John Terry before blasting a left-foot shot past the helpless Cech.
The lead, however, lasted just three minutes when, after Sunderland failed to deal fully with Juan Mata's corner, Hazard recycled the ball, wrong-footed Bardsley and crossed for Lampard to head home unopposed.
Sunderland refused to be cowed by Mourinho's men despite their freedom of movement in midfielder, and with Altidore ruffling the feathers of Terry and Gary Cahill and Dossena providing a useful outlet down the left, pressed once again.
Cech had to turn away Dossena's stinging 31st-minute effort, which may have been going wide anyway, but opposite number Mannone was not so fortunate six minutes later.
Fernando Torres helped on a long clearance to Hazard on the left and he cut inside past Bardsley and the covering Craig Gardner before firing across the Italian and into the far corner.
But Sunderland refused to give up and they were back on terms within five minutes of the restart when Giaccherini's skidding corner was allowed to reach O'Shea, who swept it past Cech to level.
Chelsea should have been back in front seven minutes later when Ramires robbed Jack Colback and fed Torres, who in turn picked out Hazard in space.
He slid past O'Shea and Ki Sung-yueng with ease before unleashing a shot which Mannone managed to beat away to Torres, who skied his follow-up high over.
But it was Hazard who did the trick once again with 62 minutes gone, collecting Lampard's intelligent back-heel and rounding O'Shea before beating the helpless Mannone with ease.
Bardsley turned substitute Demba Ba's cross into his own net six minutes from time, but then converted Sebastian Larsson's corner at the other end seconds later, although ultimately to no avail.