Sousa is relishing the prospect of taking the Swans to St James' Park and believes they can make a statement of their intent by beating Chris Hughton's side.
He told the club's official website: "They are top, but if we are at our best we will be difficult for any opposition to beat.
"If we show the same spirit and talent on Saturday, then that will include Newcastle as well.
"It will be a fantastic environment to play football and every player and manager should have the taste for it. I think we could earn respect from every other team in our division if we could beat Newcastle."