Jordan Henderson, Jack Colback and Stephane Sessegnon all come into the Black Cats' midfield, as Bruce's side attempt to end an eight-game winless run.
The trio replace John Mensah, Kieran Richardson and Steed Malbranque, with Richardson having failed a late fitness test in the Midlands.
Ahmed Elmohamady will line up at right-back, with Nedum Onuoha moving across to partner Michael Turner at centre-half.
There is a surprise substitute spot for David Meyler, who has recovered from the knee injury he sustained at Aston Villa.
BIRMINGHAM (4-4-2): Foster; Parnaby, Johnson, Ridgewell, Carr; Larsson, Ferguson, Bowyer, Gardner; Phillips, Jerome.
Subs: Doyle (gk), Davies, Mutch, Fahey, Hleb, Bentley, Derbyshire.
SUNDERLAND (4-4-2): Mignolet; Elmohamady, Turner, Onuoha, Bardsley; Henderson, Colback, Cattermole, Sessegnon; Welbeck, Gyan.
Subs: Gordon (gk), Zenden, Malbranque, Riveros, Meyler, Noble, Lynch.