Asamoah Gyan and Danny Welbeck (both hamstring) are unlikely to play again this season and Fraizer Campbell (knee) is out for a year, while even youngster Ryan Noble damaged a knee on youth team duty earlier this week.
On the spot: Sessegnon (right) scored against Wigan last weekend
Benin international Stephane Sessegnon is the main candidate for a lone role up front, while full-back Phil Bardsley has recovered from the bout of concussion he suffered during last Saturday's 4-2 victory over Wigan.
John Mensah (adductor tear) and Anton Ferdinand (hamstring) are being assessed, but Kieran Richardson (hamstring) is likely to miss out and Titus Bramble, Craig Gordon and David Meyler (all knee) remain on the sidelines.
Provisional squad: Mignolet, Carson, Onuoha, Ferdinand, Mensah, Bardsley, Angeleri, Turner, Cattermole, Muntari, Riveros, Henderson, Malbranque, Elmohamady, Sessegnon, Zenden, Colback, Knott, Adams, Lynch.
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Explore more:People: Steve Bruce, Danny Welbeck, Titus Bramble, Craig Gordon