The 15-goal striker limped out of Thursday night's Europa League success at Shakhtar Donetsk with an Achilles tendon injury.
Euro star: Zamora has been in great form domestically and in Europe
Boss Roy Hodgson will consider making changes after a gruelling trip to Ukraine and can welcome back defender Nicky Shorey and forward Stefano Okaka, who were both cup-tied.
But Hodgson's small squad is stretched with Paul Konchesky (ankle) still struggling and Andrew Johnson, Clint Dempsey and John Pantsil (all knee) sidelined.
Team (from): Schwarzer, Zuberbuhler, Baird, Kelly, Shorey, Stoor, Konchesky, Hangeland, Hughes, Smalling, Gera, Duff, Murphy, Greening, Davies, Etuhu, Riise, Nevland, Elm, Okaka, Zamora, Marsh-Brown.
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Explore more:People:ROY HODGSON, Paul Konchesky, Bobby Zamora, John Pantsil, Nicky Shorey, Andrew Johnson