Captain Lee Cattermole, strikers Danny Welbeck and Fraizer Campbell and Nedum Onuoha and Bolo Zenden will all play in the behind-closed-doors game. Bruce hopes to have all five available for Liverpool's visit to the Stadium of Light next weekend.
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Welbeck played as a substitute at Arsenal last week and with Campbell in a midweek reserves run-out. The biggest boost for Bruce will be the return of Cattermole who had feared his season was over with a back problem.
Bruce said: 'Thankfully, he's flying and happy with his back. He got a knee in the back and was diagnosed with severe bone bruising when it wouldn't get any better.
Steady progress: Craig Gordon continues to rest his knee with his manager hopeful to avoid an operation
'It was so fragile that it could have turned into a stress fracture, which was the last thing we wanted.
'When you look at us when he's in the team, he's got an infectious enthusiasm about him, which rubs off on a few others. You need people who can dig a bit, especially away from home.'
Keeper Craig Gordon continues to rest his knee and Bruce hopes the Scotland No 1 will be able to avoid an operation.
The Sunderland boss added: 'Because it's a tendon, an operation there could see him out for up to six months, if it's severe. So we're hoping a month of a special exercise regime can take away this inflammation or whatever he's got, because it's not great.'
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Explore more:People: Steve Bruce, Craig Gordon, Danny Welbeck, Lee Cattermole Places: Liverpool