The 22-year-old midfielder has been out of action since the end of December with a back problem which has required complete rest, but started running again last week and is ready to step up his bid for fitness.
Cattermole has been plagued by injuries since his ?6million switch from Wigan to the Stadium of Light - he has managed just 18 appearances to date this season, although two red cards have contributed to his absences - after missing a significant proportion of his first campaign on Wearside with a series of niggling problems.
On the mend: Sunderland midfielder Cattermole (left) is closing in on a comeback
When he has been fit, the former Middlesbrough enforcer has fully justified Bruce's faith in him, and that is why he has refused to take any chances with him.
The manager said: 'We know it's a back injury and we were worried it would turn into a stress fracture.
'That was the biggest worry and that's why he had to have complete rest, which he has done.
'The remit was that we had to give him six to eight weeks off to make sure it didn't turn into a stress fracture, and that's what we have done.
'He was in and around jogging last week and we hope that's now okay with the rest he has had.'
Cattermole was severely hampered last season by a hamstring injury stemming from a back problem, but Bruce and his medical team are confident his latest misfortune, which has sidelined him since the 2-0 Barclays Premier League home defeat by Blackpool on December 28, is unrelated.
He said: 'What happened in the past was he got a serious knee injury and then unfortunately, picked up another knock, and then a hamstring related to his back.
'But this was a whack on his back and we were worried that there was bone bruising.
'We were advised by specialists that that could turn into a stress fracture if he kept on playing, so we took him away from it and protected him.'
In addition to Cattermole's impending return, Fraizer Campbell was due to see a specialist, when he was hoping to be given the go-ahead to resume full training after a knee injury, while Michael Turner and Danny Welbeck are also nearing comebacks.
The Black Cats head for beaten Carling Cup finalists Arsenal on Saturday, desperate to end a run of four successive league defeats which has seen them drop out of the top six and slip off the pace in the race for Europa League qualification.
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