Henderson joined Liverpool from Sunderland in June for a reported £16million, but he will not be preparing any differently for the game against his former club.
"I think if I do play then I have to treat it as a normal game," he told BBC Radio Merseyside.
"It will be a massive occasion and I just have to play my game normally.
"I had a great time at Sunderland; I supported them my whole life and I have a lot of respect for the manager, the staff and the players there.
"It was a hard decision (to leave) at the time but it was a massive opportunity to come to a club like Liverpool and progress as a player."