Blackpool have made an excellent start to their season which included beating Premier League Wigan in the last round, and they will look to claim another scalp at the Britannia Stadium.
Uruguay international Diego Arismendi will make his eagerly awaited Stoke debut as Tony Pulis looks set to name a reserve side.
The 21-year-old defensive midfielder, who has impressed in two reserve outings, has been given time to settle since a £2.75million move from Club Nacional just before the transfer deadline.
None of Stoke's starting line-up from Saturday's draw at Bolton are likely to feature, but the fit again James Beattie, Tuncay, Liam Lawrence and Andy Wilkinson could be included.
Blackpool newsRookie Blackpool defender Ash Eastham has been recalled from his loan spell at Hyde United ahead of Tuesday's clash.
The 18-year-old has enjoyed an impressive stint at Ewen Fields and could be thrust into action at the Britannia Stadium.
The Seasiders are short of defenders after Ian Evatt sustained a hamstring injury in Saturday's 1-0 win at Nottingham Forest, ruling him out for at least a fortnight.