Saints, who will kick off the League One campaign on minus-10 points, host last season's losing play-off finalists Millwall on August 8.
"It's good to be drawn at home on the opening day, but Millwall will be interesting opponents," said Wotte.
"I watched them at Wembley in the final against Scunthorpe and they are a tough side to play against, but they will also find it tough coming here.
"They have a good striker in Gary Alexander, who scored twice in the final, and Millwall did well last season. But we will be ready for them.
"They have a fighting mentality and we will have to match that. It will be a good incentive in pre-season to ensure we hit the ground running."