Southampton will check on Jose Fonte ahead of the trip to Yeovil.
The Portuguese defender missed Saturday's 1-0 win at Sheffield Wednesday with a slight knock but Saints are hopeful he will be fit.
Radhi Jaidi deputised at Hillsborough and is likely to make way if Fonte comes straight back in.
Midfielder Adam Lallana made a surprise return to the squad at the weekend after four weeks out following knee surgery and should be involved again.
Striker David Connolly is set to miss out again with a stomach injury and full-back Frazer Richardson is still having treatment on a shoulder problem.
Lee Barnard will continue in attack after scoring Saints' first goal in more than eight and a half hours against the Owls.